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18/Potential proarrhythmic effect of automatic threshold testing in pacemakers

Published Online: October 3rd 2021 European Journal of Arrhythmia & Electrophysiology. 2021;7(Suppl. 1):abstr18
Authors: KA Mather (Presenting Author) - Northumbria Healthcare, North Tyneside; IG Matthews - Northumbria Healthcare, North Tyneside; C Runnett - Northumbria Healthcare, North Tyneside; HE Thomas - Northumbria Healthcare, North Tyneside,
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Background: Manufacturers of cardiac implantable electronic devices have incorporated automatic features to improve safety, allow remote monitoring and improve longevity. The Abbott Autocapture algorithm measures capture threshold by verifying impulse capture using an evoked response and adjusts the output. If the device identifies loss of capture (LOC), it delivers a back-up pulse (VPP). However, an intrinsic QRS complex may coincide with the initial impulse, and the device may interpret this as LOC and deliver a VPP. A small number of case reports describe ventricular tachyarrhythmia potentially associated with the delivery of a VPP in Abbott/SJM devices. We recognised this phenomenon in several of our patients prompting a systematic local case review.

Methods: We reviewed the local follow-up data for all Abbott pacemakers. We reviewed all ventricular high-rate episodes which had accompanying EGMs. If confirming a ventricular tachyarrhythmia (VT), we recorded any evidence of a LOC-VPP response on the EGM and classified if this immediately preceded the event or was present elsewhere on the EGM.

Results: 282 patients with Abbott pacemakers were identified. 147 patients (52%) had Autocapture actively programmed with 135 inactive. 53/147 patients with Autocapture active had episodes of VT during device follow up with only 15/135 VT episodes in those with Autocapture inactive. In the Autocapture active group, 13/53 patients were found to have LOC-VPP directly preceding a period of VT (VPP-VT group). See Figure 1 for an example EGM. An additional 12 had a VPP-LOC within the recorded EGM but not immediately preceding the VT. Of the 13 patients with VPPVT, left ventricular function was reduced in 5 (1 mild, 4 moderate), normal in 5 and unknown in 1. 4/13 of the VPP-VT group had episodes of VT prior to the index VPP-VT event; one died (during the VPP-VT event), 1 had no further episodes following Autocapture deactivation, 1 had further VT following Autocapture deactivation and 1 awaits Autocapture deactivation. In patients with no prior VT and a single episode of VPP-VT, there has been no further VT since Autocapture deactivation.

Discussion: The use of the Ventricular Autocapture algorithm in Abbott pacemakers could be associated with the apparent initiation of VT in over 8.8% of patients. We have yet to carry out systematic review of patients with other manufacturers’ devices, but anecdotally we have not identified this in these groups. The Abbott algorithm differs from other manufacturers in that the backup pulse is at 80 ms – the shortest interval of the large device manufacturers. The vast majority of our pacemakers are now remote monitored and it may be that this better allowed us to identify and investigate this issue. It may also be that our strategy of remote follow up increases Autocapture activation subsequently revealing the scale of this potential problem. We are in the process of deactivating the Autocapture in any patient with evidence of VHR in association with a LOC-VPP event and will gather data prospectively to assess the impact of this. During this investigation process, our findings have been shared with our regional cardiac network, Abbott and the MHRA.

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European Journal of Arrhythmia & Electrophysiology. 2021;7(Suppl. 1):abstr43

Introduction: Cardiac tamponade is a high morbidity complication of transseptal puncture (TSP). We examined the incidence and predictors of TSP-related cardiac tamponade (TRCT) for all patients undergoing left atrial ablation at our centre from 2016-2020. Methods: Patient and procedural variables were extracted retrospectively. Cases of cardiac tamponade were scrutinised to adjudicate TSP culpability. Adjusted multivariate […]

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