Filter Specialty
Submit To The Journals

Nitrates: new insights into old drugs

Heart International 2007;3(3-4):69-77


Nitric oxide (NO), a highly unstable gas with a half-life of a few seconds, is the most important mediator produced by endothelial cells and has several important protective functions concerning the control of vascular tone, thrombogenesis, fibrinolysis, cell proliferation, inflammation and endothelial permeability, which are crucial for the maintenance of an anti-inflammatory, anti-atherogenic and anti-thrombotic state. The exogenous administration of NO with nitrates has been proposed as possible NO exogenous sources in endothelial dysfunction therapy and coronary artery disease because of their anti-atherosclerotic effect, through a reduction in oxidative stress, on low-density lipoprotein (LDL) oxidation, chemotactic molecules and growth factors, which mediate leukocytal adhesion and proliferation of vascular smooth cells. Moreover, nitrates show a vasodilatant effect on the venous, arterial and coronary region with a consequent reduction in preload, afterload and an improvement in myocardial energetic metabolism. Due to these favorable effects nitrates are indicated not only in angina pectoris, acute myocardial infarction and pulmonary hypertension or hypertension crisis, but also in systolic and diastolic heart failure, in the prevention of ischemic and reperfusion damage after IMA or PCI and in the prevention of post-infarctual remodeling. Moreover, recent data concerning the protective effects of nitrates on endothelial function, suggest their possible use in the prevention of endothelial damage and atherogenesis. (Heart International 2007; 3: 69-77)


Nitrates, Nitric oxide, Effects, Clinical indications

Published Online

December 01, 2007


Dr. Savina Nodari, Section of Cardiovascular Diseases, Dept. of Experimental and Applied Medicine, University of Brescia c/o Spedali Civili, P.zza Spedali Civili, 1, 25123 Brescia - Italy,

  • Touch Medical Media Limited, trading as Touch Medical Media, is a private limited company registered in England and Wales at The White House, Mill Road, Goring, Reading, England, RG8 9DD with registered number 08197142. © 2019 All rights reserved.

    touchcardio is for informational purposes and intended for healthcare professionals only. Its content should not be considered medical advice, diagnosis or treatment recommendations.