A recent study by Ryan Woltzand colleagues from the Howard Hughes Medical Institute (CA, USA) in PNAS reveals that phosphatidylinositol 4,5-bisphosphate (PIP2) plays a critical role in regulating small-conductance Ca²+-activated K⁺ (SK2) channels by disrupting a key salt bridge that modulates channel activation. This discovery not only enhances our understanding of ion channel dynamics but also holds significant promise for the development of targeted therapies for atrial fibrillation (AF).
A recent study has uncovered a significant association between residential exposure to transportation noise and the risk of developing atrial fibrillation (AF). The study, published in The Lancet Regional Health - Europe reveals that individuals exposed to elevated levels of road traffic noise face a 2% increase in the risk of AF for every 10-decibel rise in noise exposure. Notably, this risk was amplified among women and those with higher body mass indices, underscoring the need for heightened awareness of environmental health risks.
The first-in-human implantation of a leadless pacing system occurred already more than 10 years ago.1 The first-generation ventricular leadless pacemaker could provide only asynchronous ventricular pacing (ventricular, ventricular, inhibited [VVI], or ventricular, ventricular, inhibited, rate response [VVIR]), limiting its indications to patients with atrial fibrillation and severe bradycardia, those precluded for implantation of a transvenous pacemaker […]
Cardiovascular disease (CVD) is a significant cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). An estimated 60–80% of patients with T2DM die of cardiovascular events.1,2 A bidirectional relationship has been noted between heart failure (HF) and T2DM.3 HF was noted to be twice as high in male patients and five times as […]
Education, Conference Coverage and Articles
Introducing the Editorial Board of Heart International, who support our mission to advance medical knowledge and practice by ensuring the integrity, relevance, and impact of the content we publish. Together, we strive to foster a vibrant academic community and contribute to the continuous improvement of healthcare worldwide.
Interventional Cardiology
Dr. Rajesh Davé is a recognized leader in cardiovascular intervention, and currently serves as Chairman, Department of Cardiology and Chief Medical Executive of Holy Spirit Cardiovascular Institute at Holy Spirit Hospital, Camp Hill, PA, USA. He is founder and chairman of the Complex Cardiovascular Catheter Therapeutics congress, known as C3. He is a frequent speaker for cardiovascular conferences around the world and has given hundreds of lectures. He is a pioneer in endovascular intervention, especially critical limb ischemia, limb salvage and carotid artery stenting. He has performed over 10,000 interventional procedures in his career. He has advised medical device start-ups regarding the designs of current and future products. He has served as Principal Investigator for a variety of clinical trials. He has authored many manuscripts and book chapters, and he serves on the editorial boards of numerous medical journals.
Interventional Cardiology
Dr Magdi El-Omar is a consultant interventional cardiologist at the Manchester Heart Centre and an honorary senior lecturer at the University of Manchester, Manchester, UK. He graduated from St Bartholomew’s Hospital, London, UK, in 1988 and undertook his postgraduate general medical training in London and Oxford. He then completed his general cardiology training in Birmingham, Oxford and Wales before subspecializing in coronary intervention. The latter included a 2.5-year clinical/research fellowship in interventional cardiology at the Cardiovascular Research Foundation and the New York University Medical Centre, New York, NY, USA. During his time there, he worked closely with leaders in the field, including doctors Greg Stone, Martin Leon, Gary Roubin, Frederick Feit and Aaron Marcus. Dr El-Omar has been involved in research for over 25 years. He undertook a 2-year British Heart Foundation Junior Research Fellowship in basic science (diabetic cardiomyopathy in a rat model) in 1997–8, which led to the award of an MD degree from the University of London. He has since been actively involved in clinical research, especially in the fields of acute coronary syndromes and coronary intervention. He has authored more than 70 peer-reviewed articles, mostly in high-impact journals. He has been a local principal investigator for several landmark, international, multicentre trials (e.g. HORIZONS-AMI, INFUSE-AMI, TOTAL, TWILIGHT, etc.). He is actively involved in education and training and is a course co-director of the International Complex Cardiovascular Catheter Therapeutics Conference in the USA.
Interventional Cardiology
Dr Samaja is a distinguished cardiologist and interventional radiologist, currently serving as the Chief of the Department of Interventional Radiology and Cardiology at Policlinico Bancario in Buenos Aires, Argentina. In addition, he is the Director of the Cardiac Catheterization Laboratory at “Sanatorio Colegiales” in Buenos AiresConsultant in Cardiovascular Disease at the “Dirección General de Obra Social del Servicio Penitenciario Federal” and various other public, union, and private health structures throughout Argentina.
Dr Samaja is an active member of several prestigious professional organizations, including the Sociedad Argentina de Cardiología (SAC), Colegio Argentino de Cardioangiólogos Intervencionistas (CACI), and Sociedad Latinoamericana de Cardiología Intervencionista (SOLACI). Additionally, he is a Fellow of The Society for Cardiovascular Angiography and Interventions (SCAI) and a member of Heart International.
As a founder member of the Interventional Academy, Dr Samaja has made significant contributions to the field of interventional cardiology. He has held over fifty faculty appointments at international scientific meetings, including CIT since 2009, C3 Orlando since 2012, and has been a faculty member at EuroPCR, TCT, India Live, Egypt, and various other meetings in Argentina, South America, and overseas.
Dr Samaja has an extensive record of scholarly contributions, with more than fifty cases, abstracts, and poster presentations as an author or coauthor at scientific meetings. His expertise and commitment to advancing cardiovascular care have made him a respected leader in his field.
Cardiovascular disease
Dr Timir Paul is a Professor of Medicine and Founding Program Director for Cardiology Fellowship at University of Tennessee Health Sciences Center at Nashville. After receiving MD, he was awarded PhD and MPH in Cardiovascular Epidemiology by Tulane University. He has served as the Founding Co-Director of the Center for Cardiovascular Risk Research at East Tennessee State University. He has authored and coauthored more than 200 publications and book chapters. He serves as an academic editor for PLOS ONE Journal and on the Editorial Board for several Cardiology Journals including Journal of the Society of Coronary Angiography and Intervention, Catheterization and Cardiovascular Intervention, Cardiovascular Revascularization Medicine and Heart International. His research and recommendations changed the 2021 ACC/AHA 2021 and 2018 European Society of Cardiology guidelines on coronary revascularization by downgrading the use of embolic protection device in vein graft intervention from Class I to Class IIa. He received several grants including a PCORI grant and a 4.5 million dollars AHRQ grant as a co-investigator. His research interests include vein graft interventions, embolic protection devices in coronary and peripheral interventions, subclinical atherosclerosis, coronary microvascular disease, and renal artery interventions. He was recognized as SCAI-Emerging Leader Mentorship Program Circle member and Young Leader by the Cardiovascular Revascularization Technologies. He is an invitee of the 2022 and 2023 ACC Leadership Forum. He received the best teaching award given by cardiology fellows for the 4 consecutive years. He was inducted by Alpha Omega Alpha Medical Honor Society as a faculty member. He received Dean’s distinguished research award. He is an invited faculty for national and international scientific conferences including SCAI, ACC, AHA and CRT. He serves on the SCAI QI and International Committee and ACC PDGME Leadership Council.
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