MF Yuyun – Cardiology and Vascular Medicine Service, VA Boston Healthcare System, Boston, MA, USA; M Newton – Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK; X Li – Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK; V Pooranachandran – Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK; Z Vali – Department of Cardiovascular Sciences, University of Leicester,