An Introduction to Atherosclerosis
Atherosclerosis is defined as the build-up of plaque in the arteries, causing the narrowing of arteries and leading to the majority of heart attacks and strokes. Statin monotherapy has long been established as the gold-standard treatment, however the treatment landscape has grown over recent years with the introduction of new lipid-lowering therapies including fibrates, ezetimibe and PCSK-9 inhibitors. Further research and large-scale clinical trials are required to better compare their efficacy and safety with standard statin therapy.
Browse the content below where leading experts discuss the latest data in video interviews and short articles from our conference hub, and browse the selection of peer-reviewed articles from our journal portfolio. If you are looking to learn more about the impact of these developments on patient outcomes, our educational activities are a great resource.
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Charalambos Antoniades, ESC 2021 – The Fat Attenuation Index
Prof. Charalambos Antoniades (Professor of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) kindly shared his thoughts on the fat attenuation index and its use in clinical decision making from the virtual ESC Congress 2021. Questions Can you tell us a little about the fat attenuation index (FAI) and how it can be […]
Charalambos Antoniades, ESC 2021 – High-sensitivity C-reactive Protein, Perivascular Adipose Tissue and Atherosclerosis
Prof. Charalambos Antoniades (Professor of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK) kindly shared his thoughts on the use of high-sensitivity C-reactive protein as a biomarker in clinical decision making, and the role of perivascular adipose tissue in the pathogenesis of atherosclerosis from the virtual ESC Congress 2021. Questions What is the […]
Stephen Nicholls, ESC 2021 – the HUYGENS Study
Prof. Stephen Nicholls (Professor of Cardiology, Monash University, Melbourne, Australia) kindly shared his thoughts on the impact of PCSK9 inhibitors on lipid-lowering therapy, the effects of statins on coronary atherosclerotic plaques and the HUYGENS study from the virtual ESC Congress 2021. Questions What has been the impact of PCSK9 inhibitors on lipid-lowering therapy, and what […]
Medical Therapy for Secondary Prevention of Atherothrombotic Events in Peripheral Artery Disease
Heart International. 2021;15(1):14-19 DOI: https://doi.org/10.17925/HI.2021.15.1.14
Peripheral artery disease (PAD) is a severe manifestation of systemic atherosclerotic disease that commonly refers to lower-extremity arterial involvement. The global burden of PAD is estimated to involve over 200 million patients, with prevalence increasing by 24% over the past decade.1 In contrast to myocardial infarction and stroke, which are declining in the USA, the […]
The Evolving Role of Omega 3 Fatty Acids in Cardiovascular Disease: Is Icosapent Ethyl the Answer?
Heart International. 2021;15(1):7-13 DOI: https://doi.org/10.17925/HI.2021.15.1.7
There are several beneficial effects of statins on the progression of atherosclerosis, and there have been significant advancements in pharmacotherapies for atherosclerotic cardiovascular disease (ASCVD). However, substantial residual cardiovascular (CV) risk remains, and there is an unmet need to reduce the residual risk of cardiovascular disease (CVD) events.1 There is increased focus on the role […]
Use of Coronary Computed Tomography for Calcium Screening of Atherosclerosis
Heart International. 2020;14(2):76-9 DOI: https://doi.org/10.17925/HI.2020.14.2.76
Cardiovascular disease (CVD) represents the prevailing cause of death in the United States.1 Cancer, accidents and other prevalent causes of death, have a multitude of pathophysiologic and mechanistic underpinnings leading to mortality. Meanwhile, the majority of CVD is primarily attributable to atherosclerosis.2 Moreover, the degree of coronary calcification strongly correlates with the magnitude of atherosclerotic plaque burden, […]
Purvi Parwani, Mamas Mamas, Martha Gulati, ESC 2018 – Social Media and Cardiology
Dr Purvi Parwani (Assistant Professor of Medicine, Loma Linda University Health, Loma Linda, CA, USA), Professor Mamas Mamas (Professor of Cardiology, University of Keele, Keele, UK) and Dr Martha Gulati (Head of Cardiology, University of Arizona College of Medicine, Phoenix, AZ, USA) discuss social media in cardiology. Filmed at ESC 2018, Munich. View more content […]
Marianne Brodmann, ESC 2018 – Antithrombotic Therapy in Patients with Lower Extremity Arterial Disease (LEAD)
Dr Marianne Brodmann (Professor of Vascular Medicine, Medical University of Graz, Graz, Austria) discusses the challenges, treatment and developments in antithrombotic therapy in patients with lower extremity arterial disease (LEAD). Filmed at ESC 2018, Munich. View more content here. Speaker Disclosure: Dr Marianne Brodmann has nothing to disclose in relation to this video interview. […]
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