Jawad Haider Butt, ESC 2022: A post hoc analysis of PARAGON-HF assessing sacubitril/valsartan in patients with HFpEF according to frailty status

The post hoc analysis of PARAGON-HF assessed the efficacy of sacubitril/valsartan, compared with valsartan, according to frailty status in patients with heart failure (HF) with preserved fraction (HFpEF). Frailty is a common issue, with patients less likely to receive pharmacological therapy due to a less favourable benefit/risk profile. In this touchCARDIO interview, we speak with Dr Jawad Haider Butt (Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark) to discuss the post-hoc analysis of PARAGON-HF data and the impact of patient frailty on clinical outcomes. 

The abstract entitled ‘Efficacy and safety of sacubitril/valsartan according to frailty in heart failure with preserved ejection fraction: a post hoc analysis of the PARAGON-HF trial’ was presented at the European Society of Cardiology (ESC) Congress 2022, 26 – 29 August 2022.

Questions:

1. What are the challenges in the treatment of frail patients with heart failure (HF)? (0:18)
2. Can you give us an overview of the PARAGON-HF trial? (2:00)
3. Could you tell us a little about the post-hoc analysis of PARAGON-HF data, and the parameters used to assess frailty? (2:44)
4. How were clinical outcomes affected by patient frailty? (4:05)
5. What did the PARAGON-HF teach us about the efficacy and safety of sacubitril/valsartan, in patients with HF with preserved fraction (HFpEF)? (5:03)
6. How can these findings be used to optimise treatment decisions in patients with HFpEF? (6:08)

Disclosures: Jawad Haider Butt is on the advisory board for Bayer.

Support: Interview and filming supported by Touch Medical Media. Interview conducted by Danielle Crosby.

Filmed as a highlight of ESC 2022

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