Nuclear stress perfusion imaging versus computed tomography coronary angiography for identifying patients with obstructive coronary artery disease as defined by conventional angiography: insights from the CorE-64 multicenter study
Abstract
Overview
We investigated the diagnostic accuracy of computed tomography angiography (CTA) versus myocardial perfusion
imaging (MPI) for detecting obstructive coronary artery disease (CAD) as defined by conventional quantitative
coronary angiography (QCA). Sixty-three patients who were enrolled in the CorE-64 multicenter study underwent
CTA, MPI, and QCA imaging. All subjects were referred for cardiac catheterization with suspected or known
coronary artery disease. The diagnostic accuracy of quantitative CTA and MPI for identifying patients with 50%
or greater coronary arterial stenosis by QCA was evaluated using receiver operating characteristic (ROC) analysis.
Pre-defined subgroups were patients with known CAD and those with a calcium score of 400 or over. Diagnostic
accuracy by ROC analysis revealed greater area under the curve (AUC) for CTA than MPI for all 63 patients: 0.95
[95% confidence interval (CI): 0.89-0.100] vs 0.65 (95%CI: 0.53-0.77), respectively (P<0.01). Sensitivity, specificity,
positive and negative predictive values were 0.93, 0.95, 0.97, 0.88, respectively, for CTA and 0.85, 0.45, 0.74, 0.63,
respectively, for MPI. In 48 patients without known CAD, AUC was 0.96 for CTA and to 0.67 for SPECT (P<0.01).
There was no significant difference in AUC for CTA in patients with calcium score below 400 versus over 400 (0.93 vs
0.95), but AUC was different for SPECT (0.61 vs 0.95; P<0.01). In a direct comparison, CTA is markedly superior to
MPI for detecting obstructive coronary artery disease in patients. Even in subgroups traditionally more challenging
for CTA, SPECT does not offer similarly good diagnostic accuracy. CTA may be considered the non-invasive test
of choice if diagnosis of obstructive CAD is the purpose of imaging.
Keywords
Cardiac computed tomography, Myocardial perfusion imaging, Myocardial ischemia.
Article Information
Disclosure
Financial support: Dr. Arbab-Zadeh is supported by a grant from the
US National Institutes of Health (K23HL098368).
Correspondence
Armin Arbab-Zadeh, MD, PhD Division of Cardiology Johns Hopkins Hospital 600 North Wolfe Street Blalock 524 Baltimore MD 21287, USA azadeh1@jhmi.edu
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