The objective of this study was to investigate the impact of image acquisition settings and patients’ characteristics on image quality and radiation dose for coronary angiography by 320-row computed tomography (CT). CORE320 is a prospective study to investigate the diagnostic performance of 320-detector CT for detecting coronary artery disease and associated myocardial ischemia. A run-in phase in 65 subjects was conducted to test the adequacy of the computed tomography angiography (CTA) acquisition protocol. Tube current, exposure window, and number of cardiac beats per acquisition were adjusted according to subjects’ gender, heart rate, and body mass index (BMI). Main outcome measures were image quality, assessed by contrast/noise measurements and qualitatively on a 4-point scale, and radiation dose, estimated by the dose-length-product. Average heart rate at image acquisition was 55.0±7.3 bpm. Median Agatston calcium score was 27.0 (interquartile range 1-330). All scans were prospectively triggered. Single heart beat image acquisition was obtained in 61 of 65 studies (94%). Sixtyone studies (94%) and 437 of 455 arterial segments (96%) were of diagnostic image quality. Estimated radiation dose was significantly greater in obese (5.3±0.4 mSv) than normal weight (4.6±0.3 mSv) or overweight (4.7±0.3 mSv) subjects (P<0.001). BMI was the strongest factor influencing image quality (odds ratio=1.457, P=0.005). The CORE320 CTA image acquisition protocol achieved a good balance between image quality and radiation dose for a 320-detector CT system. However, image quality in obese subjects was reduced compared to normal weight subjects, possibly due to tube voltage/current restrictions mandated by the study protocol.
CT angiography, image acquisition, image quality, radiation dose, body mass index, contrast to noise ratio.
Armin Arbab-Zadeh MD PhD, Associate Director, Cardiac CT, Johns Hopkins Hospital, Division of Cardiology, 600N. Wolfe St., Blalock 524, Baltimore, MD 21287, USA. Tel. +1.410.502.0549 – Fax +1.443.287.6624. E-mail: email@example.com
Share this Article
Related Content In Imaging
The Quantification of Total Coronary Atheroma Burden – A Major Step Forward
Heart International. 2020;14(2):73-5 DOI: https://doi.org/10.17925/HI.2020.14.2.73
More than half of acute coronary syndromes (ACS) occur in subjects with no significant coronary stenosis.1 In view of the number of patients dying each year from a heart attack, the question of identifying these patients is of primary importance. A large body of evidence currently exists, indicating that total coronary atheroma burden (TOCAB) – the […]
Left main Stenosis Stenting Normalizes Wall Shear Stress of Ascending Aorta in Bicuspid Aortic Valve
Heart International. 2020;14(2):121-2 DOI: https://doi.org/10.17925/HI.2020.14.2.121
Bicuspid aortic valve (BAV) represents the most common congenital cardiac anomaly, with a prevalence ranging between 1% and 2% in the general population.1 BAV is known to be associated with dilation and dissection of the ascending aorta, and the significantly higher shear forces seem to have a pivotal role on the development of such complications.2 Nowadays, patients […]
Computed Tomography-Based Patients’ Specific Biomechanical and Fluid Dynamic Study of Anomalous Coronary Arteries with Origin from the Opposite Sinus and Intramural Course
Heart International. 2020;14(2):105-11 DOI: https://doi.org/10.17925/HI.2020.14.2.105
Anomalous coronary arteries originating from the opposite sinus of Valsalva (ACAOS) is one of the most clinically relevant abnormalities among the wide spectrum of coronary artery anomalies.1 Sudden cardiac death has been related to myocardial bridges, ectopic origin of the pulmonary artery, a single coronary artery and ACAOS with an intramural course (ACAOS-IM), especially in young […]
Journal articles and more to your inbox
Get the latest clinical insights from touchCARDIOSign me up!