Home > News > 31/Long-term adverse sequelae of left ventricular leads in the context of cardiac resynchronisation therapy
Devices
Read Time: < 1 min

31/Long-term adverse sequelae of left ventricular leads in the context of cardiac resynchronisation therapy

Published Online: September 27th 2010 European Journal of Arrhythmia & Electrophysiology. 2020;6(Suppl. 1):abstr31
Authors: C Hammond (Presenting Author) - Leeds General Infirmary, Cardiology, Leeds; R Nadarajah - Leeds General Infirmary, Cardiology, Leeds; N Ali - Leeds General Infirmary, Cardiology, Leeds; F Tan - Leeds General Infirmary, Cardiology, Leeds; N Burnet - Leeds General Infirmary, Cardiology, Leeds; C Cole - Leeds General Infirmary, Cardiology, Leeds; M Paton - Leeds General Infirmary, Cardiology, Leeds; R Cubbon - Leeds General Infirmary, Cardiology, Leeds; M Kearney - Leeds General Infirmary, Cardiology, Leeds; J Gierula - Leeds General Infirmary, Cardiology, Leeds; K Witte - Leeds General Infirmary, Cardiology, Leeds; P Patel - Leeds General Infirmary, Cardiology, Leeds
Quick Links:
Article
Article Information
Article:

Background: Cardiac resynchronisation therapy (CRT) confers symptomatic and survival benefits in chronic heart failure with reduced ejection fraction (HFrEF). However, there remains a paucity of data on long-term performance of left ventricular pacing leads, including adverse sequelae.

Methods: Adult patients receiving CRT for HFrEF between 2008 and 2014 were identified retrospectively from an outpatient electronic database at a large tertiary centre (Leeds Teaching Hospitals NHS Trust). Procedural and clinical notes were accessed from individual patient records and used to ascertain post-procedural complications. Acute lead failure was defined as macro-displacement within 24 hours of index procedure. Chronic lead failure was defined as elevated pacing thresholds >24 hours post-procedure due to micro/macro displacement, premature battery depletion, lead failure, lead insulation failure or intractable phrenic nerve stimulation (PNS). Details on device-related infections were also collated.

Results: 280 patients were included, with mean (±SD) age of 74.2 years (±9.0) and 34% (96/280) receiving CRT-D. Median follow-up of patients was 7.6 years (IQR 4-9). Acute lead failure occurred in 0.71% (2/280). Chronic lead failure occurred in 1.79% (5/280). Of these, there were 4 cases of lead macro-displacement, with a median time to dislocation of 45 days, and one case of intractable PNS. Device-related infection occurred in 1.43% (4/280). All cases arose >12 months post-implant, with the identified pathogen Staphylococcus aureus in three instances and Staphylococcus epidermis in one case. All underwent successful full device explant and subsequent re-implantation.

Conclusions: In the context of CRT, left ventricular pacing leads appear to be associated with low incidence of long-term adverse sequelae over prolonged follow-up.

Article Information:

Further Resources

Share this Article
Related Content In Devices
  • Copied to clipboard!
    accredited arrow-downarrow_leftarrow-right-bluearrow-right-dark-bluearrow-right-greyarrow-right-orangearrow-right-whitearrow-right-bluearrow-up-orangeavatarcalendarchevron-down consultant-pathologist-nurseconsultant-pathologistcrosscrossdownloademailexclaimationfeedbackfiltergraph-arrowinterviewslinkmdt_iconmenumore_dots nurse-consultantpadlock patient-advocate-pathologistpatient-consultantpatientperson pharmacist-nurseplay_buttonplay-colour-tmcplay-colourAsset 1podcastprinter scenerysearch share single-doctor social_facebooksocial_googleplussocial_instagramsocial_linkedin_altsocial_linkedin_altsocial_pinterestlogo-twitter-glyph-32social_youtubeshape-star (1)tick-bluetick-orangetick-whiteticktimetranscriptup-arrowwebinar Department Location NEW TMM Corporate Services Icons-07NEW TMM Corporate Services Icons-08NEW TMM Corporate Services Icons-09NEW TMM Corporate Services Icons-10NEW TMM Corporate Services Icons-11NEW TMM Corporate Services Icons-12Salary £ TMM-Corp-Site-Icons-01TMM-Corp-Site-Icons-02TMM-Corp-Site-Icons-03TMM-Corp-Site-Icons-04TMM-Corp-Site-Icons-05TMM-Corp-Site-Icons-06TMM-Corp-Site-Icons-07TMM-Corp-Site-Icons-08TMM-Corp-Site-Icons-09TMM-Corp-Site-Icons-10TMM-Corp-Site-Icons-11TMM-Corp-Site-Icons-12TMM-Corp-Site-Icons-13TMM-Corp-Site-Icons-14TMM-Corp-Site-Icons-15TMM-Corp-Site-Icons-16TMM-Corp-Site-Icons-17TMM-Corp-Site-Icons-18TMM-Corp-Site-Icons-19TMM-Corp-Site-Icons-20TMM-Corp-Site-Icons-21TMM-Corp-Site-Icons-22TMM-Corp-Site-Icons-23TMM-Corp-Site-Icons-24TMM-Corp-Site-Icons-25TMM-Corp-Site-Icons-26TMM-Corp-Site-Icons-27TMM-Corp-Site-Icons-28TMM-Corp-Site-Icons-29TMM-Corp-Site-Icons-30TMM-Corp-Site-Icons-31TMM-Corp-Site-Icons-32TMM-Corp-Site-Icons-33TMM-Corp-Site-Icons-34TMM-Corp-Site-Icons-35TMM-Corp-Site-Icons-36TMM-Corp-Site-Icons-37TMM-Corp-Site-Icons-38TMM-Corp-Site-Icons-39TMM-Corp-Site-Icons-40TMM-Corp-Site-Icons-41TMM-Corp-Site-Icons-42TMM-Corp-Site-Icons-43TMM-Corp-Site-Icons-44TMM-Corp-Site-Icons-45TMM-Corp-Site-Icons-46TMM-Corp-Site-Icons-47TMM-Corp-Site-Icons-48TMM-Corp-Site-Icons-49TMM-Corp-Site-Icons-50TMM-Corp-Site-Icons-51TMM-Corp-Site-Icons-52TMM-Corp-Site-Icons-53TMM-Corp-Site-Icons-54TMM-Corp-Site-Icons-55TMM-Corp-Site-Icons-56TMM-Corp-Site-Icons-57TMM-Corp-Site-Icons-58TMM-Corp-Site-Icons-59TMM-Corp-Site-Icons-60TMM-Corp-Site-Icons-61TMM-Corp-Site-Icons-62TMM-Corp-Site-Icons-63TMM-Corp-Site-Icons-64TMM-Corp-Site-Icons-65TMM-Corp-Site-Icons-66TMM-Corp-Site-Icons-67TMM-Corp-Site-Icons-68TMM-Corp-Site-Icons-69TMM-Corp-Site-Icons-70TMM-Corp-Site-Icons-71TMM-Corp-Site-Icons-72