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Interventional Cardiology
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Drug-coated Balloons or Drug-eluting Stents – Determining an Optimum Strategy for Patients with High Bleeding Risk

Published Online: December 23rd 2020 Heart International. 2020;14(2):Online ahead of journal publication
Authors: Natasha H Corballis, Tha H Nyi, Vassilios S Vassiliou, Simon C Eccleshall
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Article Information

The management of patients who require percutaneous coronary intervention and are at  high risk of bleeding continues to be challenging; balancing thrombotic risk versus bleeding  risk to determine the safest duration of dual antiplatelet therapy (DAPT). With recent efforts to  determine the safety of 1 month of DAPT after implantation of a drug-eluting stent,  drug-coated balloons (DCBs) have also been explored as both have been shown superior to bare-metal stents which have  historically been used for patients with high bleeding risk. We sought to review the literature  surrounding the safety profile and bleeding events with both DCBs and drug-eluting stents, and conclude that whilst both offer safety of cessation of DAPT after 1 month, DCBs offer lower major adverse cardiovascular events.


Drug-coated balloons, drug-eluting stents, high bleeding risk, duration of dual antiplatelet therapy


**This manuscript has been accepted for publication, but may be subject to minor changes during the production process.**

Article Information:

Vassilios Vassiliou reports speaker fees from Medtronic and Daichii-Sankyo. Simon Eccleshall received speaker fees and acts as a consultant for B Braun. Natasha Corballis and Tha H Nyi have no financial or non-financial relationships or activities to declare in relation to this article.

Compliance With Ethics

This study involves a review of the literature and did not involve any studies with human or animal subjects performed by any of the authors.

Review Process

Double-blind peer review.


The named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship of this manuscript, take responsibility for the integrity of the work as a whole, and have given final approval for the version to be published.


Simon C Eccleshall, Department of Cardiology, Norfolk and Norwich University Hospital NHS Foundation Trust, Norwich NR4 7UY, UK. E: simon.eccleshall@nnuh.nhs.uk


No funding was received in the publication of this manuscript.

Open Access

This article is freely accessible at touchCARDIO.com © Touch Medical Media 2020



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