Cardiovascular Disease
Watch Time: 11 mins 50

Wolfgang Linke, ESC 2021 – Key Pathomechanisms of TTNtv-dilated Cardiomyopathy

Published Online: November 9th 2021

Dr Wolfgang Linke (Professor and Chair of Physiology, University Hospital of Münster, Münster, Germany) kindly shared his thoughts on the titin gene TTNtv and dilated cardiomyopathy from the virtual ESC Congress 2021.

Questions

  1. What is known about the correlation between variants in the titin gene (TTNtv) and the incidence of dilated cardiomyopathy (DCM), and what questions remain unanswered? (0.12)
  2. What mechanisms involving the titin protein affect cardiac function? (1.45)
  3. What TTNtv modifications are most common? (3.21)
  4. What has recent research taught us about the role of TTNtv modifications in the pathogenesis in DCM? (5.05)
  5. How can we translate this knowledge towards novel therapeutic approaches to DCM? (7.44)

Speaker disclosures: Dr Wolfgang Linke has nothing to declare in relation to this video interview.

Support: Interview and filming supported by Touch Medical Media and conducted by Heather Hall.

Filmed during a remote video call with Dr Wolfgang Linke as a highlight of ESC 2021, August 2021.

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