Read Time: 2 mins

116/Safety and feasibility of His bundle pacing at a tertiary cardiac centre

Copy Link
Published Online: Oct 3rd 2008 European Journal of Arrhythmia & Electrophysiology. 2019;5(Suppl. 1):abstr116
Authors: A Merghani (Presenting Author) - Barts Heart Centre, London, UK; C Monkhouse - Barts Heart Centre, London, UK;A Jacinto - Barts Heart Centre, London, UK; J Behar - Barts Heart Centre, London, UK; S Ahsan - Barts Heart Centre, London, UK; R Providencia - Barts Heart Centre, London, UK; MD Lowe - Barts Heart Centre, London, UK; A Chow - Barts Heart Centre, London, UK; P Moore - Barts Heart Centre, London, UK; A Muthumala - Barts Heart Centre, London, UK
Quick Links:
Article Information

Introduction: Permanent His Bundle pacing has been reported as a promising alternative to conventional right ventricular and biventricular pacing due to its ability to deliver and potentially correct intrinsic His-Purkinje conduction. We performed a medium term follow up study of patients who underwent His Bundle Pacing (HBP) to examine safety, feasibility and stability of lead parameters.
Methods: HBP was performed using a Medtronic 3830 SelectSecure lead through either a Medtronic C304 deflectable guide catheter or a C315 fixed curve guide catheter. A total of 15 patients underwent HBP, including 11 (73%) males with a mean age of 71.2 ± 9 years. Thirteen patients had documented left ventricular dysfunction. ECG abnormalities included left bundle branch block (n=4), right bundle branch block (n=3), 1st degree AV block (n=2), Mobitz type 2 second degree AV block (n=2),
complete heart block (n=3) or atrial fibrillation prior to AV node ablation (n=1). All patients had a RV pacing/defibrillator lead. Patients were followed up for a mean duration of 29.1 ± 9.1 weeks.
Results: Mean fluoroscopy time was 20.2 ± 16.4 minutes and mean radiation dose was 8 mG. Selective His capture was achieved in 6 (40%) of patients. There was no statistically significant difference between the mean threshold at implant and follow up, 1.4 ± 1.69 volts at 1 ms versus 1.27 ± 1 volts at 1 ms respectively (p=0.69) (see Figure 1). Sensing was 5.3 ± 5.4 millivolts at implant with no statistically significant difference at follow-up (p=0.4). Lead impedance was also similar at implant and follow-up, 593 ± 179 Ohms versus 423 ± 68 Ohms respectively, p=0.18. There were no reported complications during all procedures and at follow up.
Conclusion: In our case series His Bundle Pacing was found to be safe, feasible and associated with stable lead parameters during follow-up. There are several potential roles for HBP in clinical practice. Randomised control studies are necessary to define these roles and assess long term clinical efficacy.

Further Resources

Share this Article
Related Content In Arrhythmia
  • Copied to clipboard!
    accredited arrow-down-editablearrow-downarrow_leftarrow-right-bluearrow-right-dark-bluearrow-right-greenarrow-right-greyarrow-right-orangearrow-right-whitearrow-right-bluearrow-up-orangeavatarcalendarchevron-down consultant-pathologist-nurseconsultant-pathologistcrosscrossdownloademailexclaimationfeedbackfiltergraph-arrowinterviewslinkmdt_iconmenumore_dots nurse-consultantpadlock patient-advocate-pathologistpatient-consultantpatientperson pharmacist-nurseplay_buttonplay-colour-tmcplay-colourAsset 1podcastprinter scenerysearch share single-doctor social_facebooksocial_googleplussocial_instagramsocial_linkedin_altsocial_linkedin_altsocial_pinterestlogo-twitter-glyph-32social_youtubeshape-star (1)tick-bluetick-orangetick-red tick-whiteticktimetranscriptup-arrowwebinar Sponsored Department Location NEW TMM Corporate Services Icons-07NEW TMM Corporate Services Icons-08NEW TMM Corporate Services Icons-09NEW TMM Corporate Services Icons-10NEW TMM Corporate Services Icons-11NEW TMM Corporate Services Icons-12Salary £ TMM-Corp-Site-Icons-01TMM-Corp-Site-Icons-02TMM-Corp-Site-Icons-03TMM-Corp-Site-Icons-04TMM-Corp-Site-Icons-05TMM-Corp-Site-Icons-06TMM-Corp-Site-Icons-07TMM-Corp-Site-Icons-08TMM-Corp-Site-Icons-09TMM-Corp-Site-Icons-10TMM-Corp-Site-Icons-11TMM-Corp-Site-Icons-12TMM-Corp-Site-Icons-13TMM-Corp-Site-Icons-14TMM-Corp-Site-Icons-15TMM-Corp-Site-Icons-16TMM-Corp-Site-Icons-17TMM-Corp-Site-Icons-18TMM-Corp-Site-Icons-19TMM-Corp-Site-Icons-20TMM-Corp-Site-Icons-21TMM-Corp-Site-Icons-22TMM-Corp-Site-Icons-23TMM-Corp-Site-Icons-24TMM-Corp-Site-Icons-25TMM-Corp-Site-Icons-26TMM-Corp-Site-Icons-27TMM-Corp-Site-Icons-28TMM-Corp-Site-Icons-29TMM-Corp-Site-Icons-30TMM-Corp-Site-Icons-31TMM-Corp-Site-Icons-32TMM-Corp-Site-Icons-33TMM-Corp-Site-Icons-34TMM-Corp-Site-Icons-35TMM-Corp-Site-Icons-36TMM-Corp-Site-Icons-37TMM-Corp-Site-Icons-38TMM-Corp-Site-Icons-39TMM-Corp-Site-Icons-40TMM-Corp-Site-Icons-41TMM-Corp-Site-Icons-42TMM-Corp-Site-Icons-43TMM-Corp-Site-Icons-44TMM-Corp-Site-Icons-45TMM-Corp-Site-Icons-46TMM-Corp-Site-Icons-47TMM-Corp-Site-Icons-48TMM-Corp-Site-Icons-49TMM-Corp-Site-Icons-50TMM-Corp-Site-Icons-51TMM-Corp-Site-Icons-52TMM-Corp-Site-Icons-53TMM-Corp-Site-Icons-54TMM-Corp-Site-Icons-55TMM-Corp-Site-Icons-56TMM-Corp-Site-Icons-57TMM-Corp-Site-Icons-58TMM-Corp-Site-Icons-59TMM-Corp-Site-Icons-60TMM-Corp-Site-Icons-61TMM-Corp-Site-Icons-62TMM-Corp-Site-Icons-63TMM-Corp-Site-Icons-64TMM-Corp-Site-Icons-65TMM-Corp-Site-Icons-66TMM-Corp-Site-Icons-67TMM-Corp-Site-Icons-68TMM-Corp-Site-Icons-69TMM-Corp-Site-Icons-70TMM-Corp-Site-Icons-71TMM-Corp-Site-Icons-72